Adenoviruses can cause respiratory diseases, including the common cold (see adenovirus infection), but can also be used to help patients through gene therapy. They were first isolated in 1953 by investigators trying to establish cell-lines from adenoidal tissue of children removed during tonsillectomy and from military recruits with febrile illness.
All adenovirus particles are similar: non-enveloped, 60–90 nanometers in diameter. They have icosahedral symmetry easily visible in the electron microscope by negative staining and are composed of 252 capsomers: 240 "hexons" + 12 "pentons" at the vertices of an icosahedron (2-3-5 symmetry).
Related category• MICROBIOLOGY
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