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The earliest manuscripts, bound in book form, especially classical works or the scriptures. From the Latin word meaning tree-trunk, the most famous codices are Biblical manuscripts, such as the 4th-century Codex Sinaiticus and Codex Vaticanus and the 5th-century Codex Alexandricus. The term may also refer to a collection of laws.

The Codex Sinaiticus is a manuscript of the Greek Bible found in two parts in 1849 and 1859. It contains all the New Testament and about a third of the Old Testament, and was bought by the British Museum in 1933.