GENETICS & HEREDITY
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    gene mapping

    Determining the relative positions of genes on a chromosome and the distance between them. Gene mapping is crucial to understanding and developing treatments for genetic disease.

    There are two different methods of gene mapping:
    • genetic mapping
    • physical mapping
    Genetic mapping is uses "linkage analysis" to determine the relative position of genes within a chromosome. If both genes are inherited together they are considered linked. By determining which genes are linked, the relative positions of genes can be worked out.

    Physical mapping involves finding the exact position of a specific gene within a chromosome. Various techniques have been developed to do this, including creating cell hybrids for mapping out DNA in specific chromosomes.


    Related entry

       • genetic map


    Related category

       • GENETICS AND HEREDITY


    Source: National Human Genome Research Institute



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