A small, highly sensitive part of the retina
of the eye of many vertebrates, which is responsible
for detailed vision. In certain vertebrates, including primates,
a region called the fovea – the site
of greatest visual acuity – lies at the center of the macula.
|View of a human retina through an opthalmoscope,
showing fovea (darker red region at center) surrounded by macula lutea
(yellowish region). Image credit: John Moran Eye Center, University
Diseases of the macula
One of the commonest causes of vision loss in those 50 or older in developed
countries is age-related macular degeneration (ARMD), or age-related maculopathy.
This condition is caused by hardening of the arteries that nourish the retina.
ARMD deprives the sensitive retinal tissue of oxygen and nutrients that
it needs to function and, as a result, central vision deteriorates. Currently,
there is no treatment that can cure the disease or reverse its course, although
a drug called Lucentis (approved by FDA) has been shown to improve vision
affected by ARMD in controlled clinical trials.