How azathioprine worksAzathioprine reduces the efficiency of the body's immune system by preventing lymphocytes (a type of white blood cell) from multiplying. Lymphocytes destroy foreign proteins and, in autoimmune disorders, attack body proteins that the immune system considers to be foreign.
Use of azathioprineAzathioprine comes as a tablet to take by mouth. It is usually taken once or twice a day after meals. The directions on the prescription label should be followed carefully and the drug taken exactly as directed.
If azathioprine is being taken to treat rheumatoid arthritis, the doctor may start the patient on a low dose and gradually increase the dose after 6–8 weeks and then not more than once every 4 weeks. If azathioprine is being taken to prevent transplant rejection, the doctor may start the patient on a high dose and decrease the dose gradually as the patient's body adjusts to the transplant.
Azathioprine controls rheumatoid arthritis but does not cure it. It may take some time before the patient feels the full benefit of the drug. Azathioprine prevents transplant rejection only as long as the patient is taking the medication.
Azathioprine is also used to treat ulcerative colitis (a condition in which sores develop in the intestine causing pain and diarrhea).
Side effects of azathioprineAzathioprine may cause side effects. The patient's doctor should be informed if any of these symptoms are severe or do not go away: upset stomach, vomiting, diarrhea, or muscle aches. Some side effects can be serious. The following symptoms are uncommon, but if the patient's doctor should be told immediately: mouth sores, cough, lack of energy, loss of appetite, pain in the upper right part of the stomach, yellowing of the skin or eyes, flu-like symptoms, rash, blurred vision, or stomach pain.
Related category• HEALTH AND DISEASE
Source: U.S. National Library of Medicine
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