nucleophile A chemical species that donates electrons, or shares electrons, to another molecule in a substitution reaction. Nucleophiles are thus in general bases, especially anions, which are attracted to partially positively-charged atoms in a molecule; examples are nitrile, hydroxide, halide, and ammonia. Compare with electrophile. Related categories • INORGANIC CHEMISTRY • ORGANIC CHEMISTRY Also on this site: Encyclopedia of Alternative Energy & Sustainable Living Encyclopedia of History Transport Concepts & Designs (partner site) |