secretin
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Secretin molecule. Source: PubChem
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A peptide hormone produced in the S cells
of the duodenum. Secretin is released in
response to low duodenal pH caused by the presence
of hydrochloric acid from the
stomach, and stimulates the secretion of
bile from the liver,
alkaline pancreatic juice from the pancreas,
and biocarbonate from duodenal Brunner's glands. It also reduces acid secretion
from the stomach by inhibiting gastrin release
from G cells. The result of these actions is to help neutralize the pH of
the digestive products entering the duodenum from the stomach, which is
important as enzymes from the pancreas (e.g. pancreatic amylase
and pancreatic lipase) function optimally at neutral pH.
Secretin, whose function was first demonstrated in 1902, was the first substance
to be described as a hormone.
Related category
• BIOCHEMISTRY
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