A polypeptide hormone synthesized (from POMC, pre-opiomelanocortin) and secreted from corticotropes in the anterior lobe of the pituitary gland in response to the hormone corticotropin-releasing hormone (CRH) released by the hypothalamus. Adrenocorticotropic hormone (ACTH or corticotropin) is secreted in short bursts every few hours and is increased by stress. In turn, ACTH controls secretion of corticosteroids by the adrenal glands.
Adrenocorticotropic hormone (ACTH or corticotropin) consists of 39 amino acids.