It is normal for blood cells to die. The lifespan of red blood cells is about 120 days. White blood cells live less than 1 day. Platelets live about 6 days. As a result, bone marrow must constantly make new blood cells. The term "anemia" is most often used to mean a condition in which a person's number of red blood cells is too low or their red blood cells do not carry enough hemoglobin. However, in aplastic anemia, normal production of all blood cells – red cells, white cells, and platelets – slows or stops. This is because the stem cells have been damaged. The cause of this damage is often unknown.
Effects of aplastic anemia on the bodyA shortage of any one of the three main types of blood cells will have an effect on the body. In aplastic anemia, however, the body must cope with a shortage of all three types of blood cells. Severe aplastic anemia that is not treated promptly can be fatal.
The effect on the body of a shortage of each type of blood cell is described below:
Important general informationAplastic anemia is a rare condition. In the United States, about 500–1,000 people develop this type of anemia each year. It is two to three times more common in Asian countries.
The two main types of aplastic anemia are acquired and hereditary. Acquired means a person develops the condition during his or her lifetime. Hereditary means a person is born with the condition. Acquired aplastic anemia is the most common type, and it is sometimes a temporary condition. It can be triggered by exposure to:
Hereditary aplastic anemia is rare. It occurs with some inherited conditions, such as Fanconi anemia.
Severity of aplastic anemiaAplastic anemia can begin suddenly or develop slowly. It tends to get worse over time, except when a cause can be found and removed. Its severity ranges from mild to very severe.
OutlookMany people with aplastic anemia can be treated successfully if they have prompt and appropriate treatment. Some people with aplastic anemia can be cured with a bone marrow transplant.
What causes aplastic anemia?Aplastic anemia is caused by damage to stem cells in the bone marrow. Stem cells normally develop into three types of blood cells: red blood cells, white blood cells, and platelets. When stem cells are damaged, they do not grow into healthy blood cells.
In more than half of people with aplastic anemia, the cause of the damage to stem cells is unknown. Some research suggests that stem cell damage may occur because the body's immune system attacks its own cells by mistake.
Causes of acquired aplastic anemiaThe cause of acquired aplastic anemia has been linked to outside agents, as well as to diseases. Outside agents include toxins such as pesticides, arsenic, and benzene; radiation and chemotherapy used to treat cancer; and medicines such as chloromycetin (chloramphenicol), an antibiotic now rarely used in the United States. Infectious diseases also can cause aplastic anemia. Some of these diseases are hepatitis, Epstein-Barr virus, cytomegalovirus, parvovirus B19, and HIV. Autoimmune diseases, such as lupus and rheumatoid arthritis, also can cause this condition.
Causes of hereditary aplastic anemiaSome inherited genetic disorders can lead to aplastic anemia. These include Fanconi anemia, Shwachman-Diamond syndrome, and dyskeratosis congenita.
Who is at risk?Aplastic anemia is a rare condition. In the United States, about 500–1,000 people develop this type of anemia each year. It is two to three times more common in Asian countries.
People of all ages can develop aplastic anemia. Men and women are equally likely to have it. It is most common in adolescents and young adults as well as the elderly.
Aplastic anemia is more likely to develop in people who:
Signs and symptoms of anginaMost of the signs and symptoms of aplastic anemia are caused by low numbers of each of the three main types of blood cells – red blood cells, white blood cells, and platelets. Other signs and symptoms are not linked to a shortage of any particular blood cell type.
Too few red blood cellsThe most common symptom of a low red blood cell count is low energy and feeling tired. This is caused by lack of enough hemoglobin, an iron-rich protein contained in red blood cells that carries oxygen to the body. A lack of enough oxygen in the blood can cause people to feel short of breath and dizzy, especially when standing up. Since the heart must work harder to circulate the reduced amount of oxygen, symptoms also can include a rapid or irregular heartbeat or an extra or unusual sound heard during the heartbeat (heart murmur).
The hemoglobin in red blood cells gives blood its red color. Lack of hemoglobin due to a low red blood cell count can lead to pale skin, gums, and nail beds.
Too few white blood cellsWhite blood cells help fight infections. Signs and symptoms of a low white blood cell count are fevers, frequent infections which can be severe, and flu-like illnesses that linger.
Too few plateletsPeople who do not have enough platelets tend to bruise and bleed easily, and the bleeding may be hard to stop. Common types of bleeding related to too few platelets include nosebleeds, bleeding gums, pinpoint red bleeding spots on the skin, and blood in the stool. Women also may have heavy menstrual bleeding.
Other signs and symptomsAplastic anemia can cause other signs and symptoms as well. Some occur in the area of the head. These signs and symptoms include headache, tender sinuses, and white patches in the mouth (oral thrush). Other signs and symptoms are nausea and rash. A person with aplastic anemia also may have an enlarged spleen or liver.
Paroxysmal nocturnal hemoglobinuriaAbout one-third of people with aplastic anemia have a condition called paroxysmal nocturnal hemoglobinuria (PNH). This is a disorder of the red blood cells. Most people with PNH don't have any signs or symptoms. If they do occur, they may include:
DiagnosisAplastic anemia is diagnosed using a medical and family history, a physical exam, and tests to discover the type and cause of anemia. Your doctor can use these methods to find out how severe the anemia is and to decide the appropriate treatment.
Specialists involvedA person with suspected aplastic anemia may be referred to a hematologist (an expert in treating blood conditions).
Medical and family historyDuring a medical history, your doctor may ask detailed questions about many kinds of symptoms. He or she may ask if you have ever had problems with anemia, had an illness or condition that could cause anemia, or been exposed to drugs, chemicals, or radiation. The doctor will ask about medicines you are taking to see if they might be a cause of the anemia. The doctor will also ask if your family members have ever had any kind of anemia.
Physical examYour doctor will do a physical exam to see how severe the anemia is and to check for its possible causes. This exam may include:
Diagnostic tests and proceduresSeveral tests of the blood and bone marrow may be used to diagnose aplastic anemia. The reasons for testing are to:
TreatmentTreatments for aplastic anemia include:
In general, treatments for aplastic anemia can limit and prevent complications, relieve symptoms, and improve quality of life. For some, a cure may be possible. Bone marrow transplants can be a cure for those people who are eligible for a transplant. Removing a known cause of aplastic anemia (such as exposure to a toxic chemical) also can cure the disorder. Other treatments can restore blood cell counts to levels high enough so that a person can live a normal life.
Who needs treatmentPeople with mild or moderate aplastic anemia may not need treatment as long as the condition does not get worse. People with severe aplastic anemia need immediate medical treatment to prevent complications from the very low levels of blood cells in their bodies. People with very severe aplastic anemia need emergency medical care and hospitalization or the anemia can be fatal in a short time.
Blood transfusionsBlood transfusions are used to keep blood counts high enough in people with aplastic anemia. Healthy blood is taken from matched donors and then given to the person with aplastic anemia through an injection in a vein. Blood transfusions help relieve symptoms. They are not an effective long-term treatment.
Red blood cells
Bone marrow transplantationA bone marrow transplant replaces damaged stem cells in bone marrow with healthy stem cells from a donor's bone marrow. It is the best treatment choice for eligible people because it usually cures aplastic anemia.
A bone marrow transplant works best in children and young adults with severe aplastic anemia who are in good health and who have matched donors. Older people are less able to tolerate the treatments needed to prepare the body for the transplant. They also are more likely to have complications after the transplant. There are age limits for who can receive a bone marrow transplant, but they vary among hospitals.
Finding a donor
Receiving the transplantBone marrow transplants are done in special units in hospitals to try to protect the person with aplastic anemia from any infections. Before the transplant, the person receives high doses of chemotherapy, radiation therapy, or both. These treatments destroy the abnormal bone marrow that is not producing blood cells.
A sample of bone marrow is taken from the donor and is given to the recipient through a vein. The donated bone marrow stem cells travel to the recipient's bone marrow and start to make healthy blood cells. If the transplant is successful, the new stem cells multiply and begin making new, healthy blood cells within 3 to 4 weeks.
Possible complicationsAfter a bone marrow transplant, the recipient is in the hospital for weeks or months. During this time, he or she is isolated and closely watched for infections and other complications. Complications are most likely to occur in the first 100 days after a transplant. Complications include rejection of the graft and what is called graft-versus-host disease (GVHD).
Medicines to stimulate bone marrowManmade versions of substances that occur naturally in the body are used to stimulate the bone marrow to produce more blood cells. Bone marrow that can produce more blood cells can help a person with aplastic anemia avoid blood transfusions. An increased number of white cells can help protect a person from infection. Examples of bone marrow stimulation medicines used to treat aplastic anemia are:
Medicines to suppress the immune systemSince research suggests that aplastic anemia may occur because the body's immune system attacks its own cells by mistake, certain medicines may be used to suppress the body's immune system. They allow the bone marrow to start making blood cells again, and they help avoid the need for blood transfusions. Medicines that suppress the immune system do not cure aplastic anemia, but they can relieve its symptoms and reduce its complications.
These medicines are often used for people who are not good candidates for a bone marrow transplant or who are waiting for a bone marrow transplant.
There are three medicines – often given together – that will suppress the body's immune system:
Medicines that suppress the immune system can have side effects. They also may increase the risk of developing leukemia or myelodysplasia. Leukemia is a type of cancer in which the number of white blood cells increases. MDS is a condition in which the bone marrow produces too many defective blood cells.
AntibioticsAntibiotics and antivirals are given to people with aplastic anemia to prevent and treat infections.
Living with aplastic anemiaMany people with aplastic anemia can be treated successfully and some can be cured. Most people are able to resume their normal activities after treatment. If you are being treated for aplastic anemia, it may take a long time to get a good response from your treatment. You may need repeated treatments, or you may need to try several treatments before finding one that works.
Lifelong followup is needed to make sure the disorder doesn't return, as well as to check for possible complications.
Ongoing health care needsTreatment for aplastic anemia can result in side effects or complications. Your doctor can talk with you about how to cope with symptoms of aplastic anemia, side effects of treatment, and complications from treatment.
Recommended physical activity
Related category• HEALTH AND DISEASE
Source: U.S. National Heart, Lung and Blood Institute
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